학술논문
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Document Type
article
Author
Josepmaria Argemi; Maria U. Latasa; Stephen R. Atkinson; Ilya O. Blokhin; Veronica Massey; Joel P. Gue; Joaquin Cabezas; Juan J. Lozano; Derek Van Booven; Aaron Bell; Sheng Cao; Lawrence A. Vernetti; Juan P. Arab; Meritxell Ventura-Cots; Lia R. Edmunds; Constantino Fondevila; Peter Stärkel; Laurent Dubuquoy; Alexandre Louvet; Gemma Odena; Juan L. Gomez; Tomas Aragon; Jose Altamirano; Juan Caballeria; Michael J. Jurczak; D. Lansing Taylor; Carmen Berasain; Claes Wahlestedt; Satdarshan P. Monga; Marsha Y. Morgan; Pau Sancho-Bru; Philippe Mathurin; Shinji Furuya; Carolin Lackner; Ivan Rusyn; Vijay H. Shah; Mark R. Thursz; Jelena Mann; Matias A. Avila; Ramon Bataller
Source
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.