학술논문
Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance
Document Type
article
Author
Natália C.C. de Azevedo Fernandes; Juliana M. Guerra; Josué Díaz-Delgado; Mariana S. Cunha; Leila delC. Saad; Silvia D. Iglezias; Rodrigo A. Ressio; Cinthya dos Santos Cirqueira; Cristina T. Kanamura; Isis P. Jesus; Adriana Y. Maeda; Fernanda G.S. Vasami; Júlia de Carvalho; Leonardo J.T. de Araújo; Renato Pereira de Souza; Juliana S. Nogueira; Roberta M.F. Spinola; José L. Catão-Dias
Source
Emerging Infectious Diseases, Vol 27, Iss 1, Pp 47-56 (2021)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
A major outbreak of yellow fever (YF) occurred in Brazil during 2016–2018. Epizootics in New World nonhuman primates are sentinel events for YF virus circulation. However, genus-specific susceptibilities and suitability for YF surveillance remain poorly understood. We obtained and compared epidemiologic, histopathologic, immunohistochemical, and molecular results from 93 human and 1,752 primate cases submitted during the recent YF outbreak in Brazil (2017), with the support of the Brazilian National YF Surveillance Program. We detected heterogeneous YF-associated profiles among the various genera of primates we analyzed. Alouatta primates were the most reliable sentinel; Sapajus and Callicebus primates had higher viral loads but lower proportional mortality rates. Callithrix primates were the least sensitive, showing lower viral loads, lower proportional mortality rates, and no demonstrable YF virus antigen or extensive lesions in liver, despite detectable viral RNA. These differences in susceptibility, viral load, and mortality rates should be considered in strategic surveillance of epizootics and control measures for YF.