학술논문
Identical twins carry a persistent epigenetic signature of early genome programming
Document Type
article
Author
Jenny van Dongen; Scott D. Gordon; Allan F. McRae; Veronika V. Odintsova; Hamdi Mbarek; Charles E. Breeze; Karen Sugden; Sara Lundgren; Juan E. Castillo-Fernandez; Eilis Hannon; Terrie E. Moffitt; Fiona A. Hagenbeek; Catharina E. M. van Beijsterveldt; Jouke Jan Hottenga; Pei-Chien Tsai; BIOS Consortium; Genetics of DNA Methylation Consortium; Josine L. Min; Gibran Hemani; Erik A. Ehli; Franziska Paul; Claudio D. Stern; Bastiaan T. Heijmans; P. Eline Slagboom; Lucia Daxinger; Silvère M. van der Maarel; Eco J. C. de Geus; Gonneke Willemsen; Grant W. Montgomery; Bruno Reversade; Miina Ollikainen; Jaakko Kaprio; Tim D. Spector; Jordana T. Bell; Jonathan Mill; Avshalom Caspi; Nicholas G. Martin; Dorret I. Boomsma
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature in adult somatic tissues.