학술논문
Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity
Document Type
article
Author
David Bradley; Alan J. Smith; Alecia Blaszczak; Dharti Shantaram; Stephen M. Bergin; Anahita Jalilvand; Valerie Wright; Kathleen L. Wyne; Revati S. Dewal; Lisa A. Baer; Katherine R. Wright; Kristin I. Stanford; Bradley Needleman; Stacy Brethauer; Sabrena Noria; David Renton; Joshua J. Joseph; Amy Lovett-Racke; Joey Liu; Willa A. Hsueh
Source
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Murine models of obesity suggest that decreases in the adipose tissue regulatory T cell compartment may contribute to insulin resistance, but how this corresponds in the human clinical context is less well understood. Here the authors propose a role for interferon gamma in shrinking the adipose tissue regulatory T cell compartment seen in human obesity and assess the alterations seen during induction of dietary changes.