학술논문
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
Document Type
article
Author
Shaobo Li; Natalia Spitz; Akram Ghantous; Sarina Abrishamcar; Brigitte Reimann; Irene Marques; Matt J. Silver; Sofía Aguilar-Lacasaña; Negusse Kitaba; Faisal I. Rezwan; Stefan Röder; Lea Sirignano; Johanna Tuhkanen; Giulia Mancano; Gemma C. Sharp; Catherine Metayer; Libby Morimoto; Dan J. Stein; Heather J. Zar; Rossella Alfano; Tim Nawrot; Congrong Wang; Eero Kajantie; Elina Keikkala; Sanna Mustaniemi; Justiina Ronkainen; Sylvain Sebert; Wnurinham Silva; Marja Vääräsmäki; Vincent W. V. Jaddoe; Robin M. Bernstein; Andrew M. Prentice; Marta Cosin-Tomas; Terence Dwyer; Siri Eldevik Håberg; Zdenko Herceg; Maria C. Magnus; Monica Cheng Munthe-Kaas; Christian M. Page; Maja Völker; Maria Gilles; Tabea Send; Stephanie Witt; Lea Zillich; Luigi Gagliardi; Lorenzo Richiardi; Darina Czamara; Katri Räikkönen; Lida Chatzi; Marina Vafeiadi; S. Hasan Arshad; Susan Ewart; Michelle Plusquin; Janine F. Felix; Sophie E. Moore; Martine Vrijheid; John W. Holloway; Wilfried Karmaus; Gunda Herberth; Ana Zenclussen; Fabian Streit; Jari Lahti; Anke Hüls; Thanh T. Hoang; Stephanie J. London; Joseph L. Wiemels
Source
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Subject
Language
English
ISSN
2399-3642
Abstract
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P