학술논문
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis
Document Type
article
Author
Ivo S. Muskens; Shaobo Li; Thomas Jackson; Natalina Elliot; Helen M. Hansen; Swe Swe Myint; Priyatama Pandey; Jeremy M. Schraw; Ritu Roy; Joaquin Anguiano; Katerina Goudevenou; Kimberly D. Siegmund; Philip J. Lupo; Marella F. T. R. de Bruijn; Kyle M. Walsh; Paresh Vyas; Xiaomei Ma; Anindita Roy; Irene Roberts; Joseph L. Wiemels; Adam J. de Smith
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Down syndrome has a high co-morbidity with immune and hematopoietic disorders. Here, the authors perform an epigenome-wide association study in newborns with and without Down syndrome to find differential methylation across the genome, including in hematopoietic regulators RUNX1 and FLI1.