학술논문
Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy
Document Type
article
Author
Alejandro David Bendala Estrada; Jorge Calderón Parra; Eduardo Fernández Carracedo; Antonio Muiño Míguez; Antonio Ramos Martínez; Elena Muñez Rubio; Manuel Rubio-Rivas; Paloma Agudo; Francisco Arnalich Fernández; Vicente Estrada Perez; María Luisa Taboada Martínez; Anxela Crestelo Vieitez; Paula Maria Pesqueira Fontan; Marta Bustamante; Santiago J. Freire; Isabel Oriol-Bermúdez; Arturo Artero; Julián Olalla Sierra; María Areses Manrique; H. Francisco Javier Carrasco-Sánchez; Vanessa Carolina Vento; Gema María García García; Pablo Cubero-Morais; José-Manuel Casas-Rojo; Jesús Millán Núñez-Cortés
Source
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-23 (2021)
Subject
Language
English
ISSN
1471-2334
Abstract
Abstract Background Since December 2019, the COVID-19 pandemic has changed the concept of medicine. This work aims to analyze the use of antibiotics in patients admitted to the hospital due to SARS-CoV-2 infection. Methods This work analyzes the use and effectiveness of antibiotics in hospitalized patients with COVID-19 based on data from the SEMI-COVID-19 registry, an initiative to generate knowledge about this disease using data from electronic medical records. Our primary endpoint was all-cause in-hospital mortality according to antibiotic use. The secondary endpoint was the effect of macrolides on mortality. Results Of 13,932 patients, antibiotics were used in 12,238. The overall death rate was 20.7% and higher among those taking antibiotics (87.8%). Higher mortality was observed with use of all antibiotics (OR 1.40, 95% CI 1.21–1.62; p