학술논문

PTCL, NOS: An update on classification, risk-stratification, and treatment
Document Type
article
Source
Frontiers in Oncology, Vol 13 (2023)
Subject
PTCL-NOS
PTCL
GATA-3
risk stratification
classification
treatment
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Language
English
ISSN
2234-943X
Abstract
The peripheral T-cell lymphomas (PTCL) are relatively rare, heterogeneous, and therapeutically challenging. While significant therapeutic gains and improved understanding of disease pathogenesis have been realized for selected PTCL subtypes, the most common PTCL in North America remains “not otherwise specified (NOS)” and is an unmet need. However, improved understanding of the genetic landscape and ontogeny for the PTCL subtypes currently classified as PTCL, NOS have been realized, and have significant therapeutic implications, which will be reviewed here.