학술논문
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne
Document Type
article
Author
Christos Petridis; Alexander A. Navarini; Nick Dand; Jake Saklatvala; David Baudry; Michael Duckworth; Michael H. Allen; Charles J. Curtis; Sang Hyuck Lee; A. David Burden; Alison Layton; Veronique Bataille; Andrew E. Pink; The Acne Genetic Study Group; Isabelle Carlavan; Johannes J. Voegel; Timothy D. Spector; Richard C. Trembath; John A. McGrath; Catherine H. Smith; Jonathan N. Barker; Michael A. Simpson
Source
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.