학술논문
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
Document Type
article
Author
Mariya B. Shapiro; Tracy Cheever; Delphine C. Malherbe; Shilpi Pandey; Jason Reed; Eun Sung Yang; Keyun Wang; Amarendra Pegu; Xuejun Chen; Don Siess; David Burke; Heidi Henderson; Rebecca Lewinsohn; Miranda Fischer; Jeffrey J. Stanton; Michael K. Axthelm; Christoph Kahl; Byung Park; Anne D. Lewis; Jonah B. Sacha; John R. Mascola; Ann J. Hessell; Nancy L. Haigwood
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective using either bNAbs or ART.