학술논문
Staphylococcus aureus surgical site infection rates in 5 European countries
Document Type
article
Author
Sibylle C. Mellinghoff; Caroline Bruns; Markus Albertsmeier; Juliane Ankert; Louis Bernard; Sofia Budin; Camille Bataille; Annika Y. Classen; Florian B. Cornely; Elodie Couvé-Deacon; Maria Fernandez Ferrer; Jesús Fortún; Alicia Galar; Eva Grill; Thomas Guimard; Jürgen A. Hampl; Sebastian Wingen-Heimann; Juan P. Horcajada; Felix Köhler; Carolin Koll; Joan Mollar; Patricia Muñoz; Mathias W. Pletz; Jule Rutz; Jon Salmanton-García; Harald Seifert; Ferdinand Serracino-Inglott; Alex Soriano; Jannik Stemler; Janne J. Vehreschild; Tim O. Vilz; Jan-Hendrik Naendrup; Oliver A. Cornely; Blasius J. Liss
Source
Antimicrobial Resistance and Infection Control, Vol 12, Iss 1, Pp 1-12 (2023)
Subject
Language
English
ISSN
2047-2994
Abstract
Abstract Objective To determine the overall and procedure-specific incidence of surgical site infections (SSI) caused by Staphylococcus aureus (S. aureus) as well as risk factors for such across all surgical disciplines in Europe. Methods This is a retrospective cohort of patients with surgical procedures performed at 14 European centres in 2016, with a nested case–control analysis. S. aureus SSI were identified by a semi-automated crossmatching bacteriological and electronic health record data. Within each surgical procedure, cases and controls were matched using optimal propensity score matching. Results A total of 764 of 178 902 patients had S. aureus SSI (0.4%), with 86.0% of these caused by methicillin susceptible and 14% by resistant pathogens. Mean S. aureus SSI incidence was similar for all surgical specialties, while varying by procedure. Conclusions This large procedure-independent study of S. aureus SSI proves a low overall infection rate of 0.4% in this cohort. It provides proof of principle for a semi-automated approach to utilize big data in epidemiological studies of healthcare-associated infections. Trials registration The study was registered at clinicaltrials.gov under NCT03353532 (11/2017).