학술논문
Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT
Document Type
article
Author
Gavin D Perkins; Chen Ji; Felix Achana; John JM Black; Karl Charlton; James Crawford; Adam de Paeztron; Charles Deakin; Mark Docherty; Judith Finn; Rachael T Fothergill; Simon Gates; Imogen Gunson; Kyee Han; Susie Hennings; Jessica Horton; Kamran Khan; Sarah Lamb; John Long; Joshua Miller; Fionna Moore; Jerry Nolan; Lyndsey O’Shea; Stavros Petrou; Helen Pocock; Tom Quinn; Nigel Rees; Scott Regan; Andy Rosser; Charlotte Scomparin; Anne Slowther; Ranjit Lall
Source
Health Technology Assessment, Vol 25, Iss 25 (2021)
Subject
Language
English
ISSN
1366-5278
2046-4924
2046-4924
Abstract
Background: Adrenaline has been used as a treatment for cardiac arrest for many years, despite uncertainty about its effects on long-term outcomes and concerns that it may cause worse neurological outcomes. Objectives: The objectives were to evaluate the effects of adrenaline on survival and neurological outcomes, and to assess the cost-effectiveness of adrenaline use. Design: This was a pragmatic, randomised, allocation-concealed, placebo-controlled, parallel-group superiority trial and economic evaluation. Costs are expressed in Great British pounds and reported in 2016/17 prices. Setting: This trial was set in five NHS ambulance services in England and Wales. Participants: Adults treated for an out-of-hospital cardiac arrest were included. Patients were ineligible if they were pregnant, if they were aged