학술논문
An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
Document Type
article
Author
Gianluigi Li Bassi; Jacky Y. Suen; Heidi J. Dalton; Nicole White; Sally Shrapnel; Jonathon P. Fanning; Benoit Liquet; Samuel Hinton; Aapeli Vuorinen; Gareth Booth; Jonathan E. Millar; Simon Forsyth; Mauro Panigada; John Laffey; Daniel Brodie; Eddy Fan; Antoni Torres; Davide Chiumello; Amanda Corley; Alyaa Elhazmi; Carol Hodgson; Shingo Ichiba; Carlos Luna; Srinivas Murthy; Alistair Nichol; Pauline Yeung Ng; Mark Ogino; Antonio Pesenti; Huynh Trung Trieu; John F. Fraser; the COVID-19 Critical Care Consortium
Source
Critical Care, Vol 25, Iss 1, Pp 1-22 (2021)
Subject
Language
English
ISSN
1364-8535
41230574
41230574
Abstract
Abstract Background Heterogeneous respiratory system static compliance (C RS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-case series or studies conducted at a national level. Methods We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe C RS—calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)]—and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide. Results We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of C RS within the first seven days of MV. Median (IQR) age was 62 (52–71), patients were predominantly males (68%) and from Europe/North and South America (88%). C RS, within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (p = 0.417) nor with PaO2/FiO2 (p = 0.100). Females presented lower C RS than males (95% CI of C RS difference between females-males: − 11.8 to − 7.4 mL/cmH2O p