학술논문

Towards Precision Psychiatry: Statistical Platform for the Personalized Characterization of Natural Behaviors
Document Type
article
Source
Frontiers in Neurology, Vol 7 (2016)
Subject
Parkinson Disease
Schizophrenia
autism
Motor control disorders
precision medicine
stochastic analyses
Neurology. Diseases of the nervous system
RC346-429
Language
English
ISSN
1664-2295
Abstract
There is a critical need for new analytics to personalize behavioral data analysis across different fields, including kinesiology, sports science and behavioral neuroscience. Specifically, to better translate and integrate basic research into patient care we need to radically transform the methods by which we describe and interpret movement data. Here we show that hidden in the ‘noise’, smoothed out by averaging movement kinematics data, lies a wealth of information that selectively differentiates neurological and mental disorders such as Parkinson’s disease (PD), deafferentation, Autism Spectrum Disorders (ASD), and Schizophrenia (SZ) from typically developing and typically aging controls. In this report we quantify the continuous forward-and-back pointing movements of participants from a large heterogeneous cohort comprising typical and pathological cases. We empirically estimate the statistical parameters of the probability distributions for each individual in the cohort and report the parameter ranges for each clinical group after characterization of healthy developing and aging groups. We coin this newly proposed platform for individualized behavioral analyses ‘precision phenotyping’ to distinguish it from the type of observational-behavioral phenotyping prevalent in clinical studies or from the ‘one-size-fits-all’ model in basic movement science. We further propose the use of this platform as a unifying statistical framework to characterize brain disorders of known etiology in relation to idiopathic neurological disorders with similar phenotypic manifestations.