학술논문
An unexpected protein interaction promotes drug resistance in leukemia
Document Type
article
Author
Aaron Pitre; Yubin Ge; Wenwei Lin; Yao Wang; Yu Fukuda; Jamshid Temirov; Aaron H. Phillips; Jennifer L. Peters; Yiping Fan; Jing Ma; Amanda Nourse; Chandrima Sinha; Hai Lin; Richard Kriwacki; James R. Downing; Tanja A. Gruber; Victoria E. Centonze; Anjaparavanda P. Naren; Taosheng Chen; John D. Schuetz
Source
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.