학술논문
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
Document Type
article
Author
Peter K. Joshi; Nicola Pirastu; Katherine A. Kentistou; Krista Fischer; Edith Hofer; Katharina E. Schraut; David W. Clark; Teresa Nutile; Catriona L. K. Barnes; Paul R. H. J. Timmers; Xia Shen; Ilaria Gandin; Aaron F. McDaid; Thomas Folkmann Hansen; Scott D. Gordon; Franco Giulianini; Thibaud S. Boutin; Abdel Abdellaoui; Wei Zhao; Carolina Medina-Gomez; Traci M. Bartz; Stella Trompet; Leslie A. Lange; Laura Raffield; Ashley van der Spek; Tessel E. Galesloot; Petroula Proitsi; Lisa R. Yanek; Lawrence F. Bielak; Antony Payton; Federico Murgia; Maria Pina Concas; Ginevra Biino; Salman M. Tajuddin; Ilkka Seppälä; Najaf Amin; Eric Boerwinkle; Anders D. Børglum; Archie Campbell; Ellen W. Demerath; Ilja Demuth; Jessica D. Faul; Ian Ford; Alessandro Gialluisi; Martin Gögele; MariaElisa Graff; Aroon Hingorani; Jouke-Jan Hottenga; David M. Hougaard; Mikko A. Hurme; M. Arfan Ikram; Marja Jylhä; Diana Kuh; Lannie Ligthart; Christina M. Lill; Ulman Lindenberger; Thomas Lumley; Reedik Mägi; Pedro Marques-Vidal; Sarah E. Medland; Lili Milani; Reka Nagy; William E. R. Ollier; Patricia A. Peyser; Peter P. Pramstaller; Paul M. Ridker; Fernando Rivadeneira; Daniela Ruggiero; Yasaman Saba; Reinhold Schmidt; Helena Schmidt; P. Eline Slagboom; Blair H. Smith; Jennifer A. Smith; Nona Sotoodehnia; Elisabeth Steinhagen-Thiessen; Frank J. A. van Rooij; André L. Verbeek; Sita H. Vermeulen; Peter Vollenweider; Yunpeng Wang; Thomas Werge; John B. Whitfield; Alan B. Zonderman; Terho Lehtimäki; Michele K. Evans; Mario Pirastu; Christian Fuchsberger; Lars Bertram; Neil Pendleton; Sharon L. R. Kardia; Marina Ciullo; Diane M. Becker; Andrew Wong; Bruce M. Psaty; Cornelia M. van Duijn; James G. Wilson; J. Wouter Jukema; Lambertus Kiemeney; André G. Uitterlinden; Nora Franceschini; Kari E. North; David R. Weir; Andres Metspalu; Dorret I. Boomsma; Caroline Hayward; Daniel Chasman; Nicholas G. Martin; Naveed Sattar; Harry Campbell; Tōnu Esko; Zoltán Kutalik; James F. Wilson
Source
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.