학술논문
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Document Type
article
Author
Latha Kadalayil; Md. Zahangir Alam; Cory Haley White; Akram Ghantous; Esther Walton; Olena Gruzieva; Simon Kebede Merid; Ashish Kumar; Ritu P. Roy; Olivia Solomon; Karen Huen; Brenda Eskenazi; Peter Rzehak; Veit Grote; Jean-Paul Langhendries; Elvira Verduci; Natalia Ferre; Darek Gruszfeld; Lu Gao; Weihua Guan; Xuehuo Zeng; Enrique F. Schisterman; John F. Dou; Kelly M. Bakulski; Jason I. Feinberg; Munawar Hussain Soomro; Giancarlo Pesce; Nour Baiz; Elena Isaevska; Michelle Plusquin; Marina Vafeiadi; Theano Roumeliotaki; Sabine A. S. Langie; Arnout Standaert; Catherine Allard; Patrice Perron; Luigi Bouchard; Evelien R. van Meel; Janine F. Felix; Vincent W. V. Jaddoe; Paul D. Yousefi; Cecilia H. Ramlau-Hansen; Caroline L. Relton; Elmar W. Tobi; Anne P. Starling; Ivana V. Yang; Maria Llambrich; Gillian Santorelli; Johanna Lepeule; Lucas A. Salas; Mariona Bustamante; Susan L. Ewart; Hongmei Zhang; Wilfried Karmaus; Stefan Röder; Ana Claudia Zenclussen; Jianping Jin; Wenche Nystad; Christian M. Page; Maria Magnus; Dereje D. Jima; Cathrine Hoyo; Rachel L. Maguire; Tuomas Kvist; Darina Czamara; Katri Räikkönen; Tong Gong; Vilhelmina Ullemar; Sheryl L. Rifas-Shiman; Emily Oken; Catarina Almqvist; Robert Karlsson; Jari Lahti; Susan K. Murphy; Siri E. Håberg; Stephanie London; Gunda Herberth; Hasan Arshad; Jordi Sunyer; Regina Grazuleviciene; Dana Dabelea; Régine P. M. Steegers-Theunissen; Ellen A. Nohr; Thorkild I. A. Sørensen; Liesbeth Duijts; Marie-France Hivert; Vera Nelen; Maja Popovic; Manolis Kogevinas; Tim S. Nawrot; Zdenko Herceg; Isabella Annesi-Maesano; M. Daniele Fallin; Edwina Yeung; Carrie V. Breton; Berthold Koletzko; Nina Holland; Joseph L. Wiemels; Erik Melén; Gemma C. Sharp; Matt J. Silver; Faisal I. Rezwan; John W. Holloway
Source
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-23 (2023)
Subject
Language
English
ISSN
1868-7083
65554760
65554760
Abstract
Abstract Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear. Methods We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1–11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points. Results We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values