학술논문
Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
Document Type
article
Author
Katrin Aslan; Verena Turco; Jens Blobner; Jana K. Sonner; Anna Rita Liuzzi; Nicolás Gonzalo Núñez; Donatella De Feo; Philipp Kickingereder; Manuel Fischer; Ed Green; Ahmed Sadik; Mirco Friedrich; Khwab Sanghvi; Michael Kilian; Frederik Cichon; Lara Wolf; Kristine Jähne; Anna von Landenberg; Lukas Bunse; Felix Sahm; Daniel Schrimpf; Jochen Meyer; Allen Alexander; Gianluca Brugnara; Ralph Röth; Kira Pfleiderer; Beate Niesler; Andreas von Deimling; Christiane Opitz; Michael O. Breckwoldt; Sabine Heiland; Martin Bendszus; Wolfgang Wick; Burkhard Becher; Michael Platten
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Modeling patient-individual resistance to immunotherapy is challenging. Here, the authors use a syngeneic experimental hypermutated orthotopic glioma model to define radiological and biological features that can predict or explain the mechanistic differences between responders and non-responders to immunotherapy.