학술논문
Intrapancreatic fat deposition is unrelated to liver steatosis in metabolic dysfunction-associated steatotic liver disease
Document Type
article
Author
Anne Linde Mak; Nienke Wassenaar; Anne-Marieke van Dijk; Marian Troelstra; Veera Houttu; Koen van Son; Stan Driessen; Diona Zwirs; Sandra van den Berg-Faay; Elizabeth Shumbayawonda; Jurgen Runge; Michail Doukas; Joanne Verheij; Ulrich Beuers; Max Nieuwdorp; Djuna L. Cahen; Aart Nederveen; Oliver Gurney-Champion; Adriaan Holleboom
Source
JHEP Reports, Vol 6, Iss 3, Pp 100998- (2024)
Subject
Language
English
ISSN
2589-5559
Abstract
Background & Aims: Individuals with obesity may develop intrapancreatic fat deposition (IPFD) and fatty pancreas disease (FPD). Whether this causes inflammation and fibrosis and leads to pancreatic dysfunction is less established than for liver damage in metabolic dysfunction-associated steatotic liver disease (MASLD). Moreover, the interrelations of FPD and MASLD are poorly understood. Therefore, we aimed to assess IPFD and fibro-inflammation in relation to pancreatic function and liver disease severity in individuals with MASLD. Methods: Seventy-six participants from the Amsterdam MASLD-MASH cohort (ANCHOR) study underwent liver biopsy and multiparametric MRI of the liver and pancreas, consisting of proton-density fat fraction sequences, T1 mapping and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). Results: The prevalence of FPD was 37.3%. There was a clear correlation between pancreatic T1 relaxation time, which indicates fibro-inflammation, and parameters of glycemic dysregulation, namely HbA1c (R = 0.59; p