학술논문
Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction
Document Type
article
Author
Zhenhua Liu; Nannan Yang; Jie Dong; Wotu Tian; Lisa Chang; Jinghong Ma; Jifeng Guo; Jieqiong Tan; Ao Dong; Kaikai He; Jingheng Zhou; Resat Cinar; Junbing Wu; Armando G. Salinas; Lixin Sun; Mantosh Kumar; Breanna T. Sullivan; Braden B. Oldham; Vanessa Pitz; Mary B. Makarious; Jinhui Ding; Justin Kung; Chengsong Xie; Sarah L. Hawes; Lupeng Wang; Tao Wang; Piu Chan; Zhuohua Zhang; Weidong Le; Shengdi Chen; David M. Lovinger; Cornelis Blauwendraat; Andrew B. Singleton; Guohong Cui; Yulong Li; Huaibin Cai; Beisha Tang
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits.