학술논문
Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
Document Type
article
Author
Juliana M. Sá; Sarah R. Kaslow; Roberto R. Moraes Barros; Nicholas F. Brazeau; Christian M. Parobek; Dingyin Tao; Rebecca E. Salzman; Tyler J. Gibson; Soundarapandian Velmurugan; Michael A. Krause; Viviana Melendez-Muniz; Whitney A. Kite; Paul K. Han; Richard T. Eastman; Adam Kim; Evan G. Kessler; Yonas Abebe; Eric R. James; Sumana Chakravarty; Sachy Orr-Gonzalez; Lynn E. Lambert; Theresa Engels; Marvin L. Thomas; Pius S. Fasinu; David Serre; Robert W. Gwadz; Larry Walker; Derrick K. DeConti; Jianbing Mu; Jeffrey A. Bailey; B. Kim Lee Sim; Stephen L. Hoffman; Michael P. Fay; Rhoel R. Dinglasan; Jonathan J. Juliano; Thomas E. Wellems
Source
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.