학술논문
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
Document Type
article
Author
Xintao Qiu; Nadia Boufaied; Tarek Hallal; Avery Feit; Anna de Polo; Adrienne M. Luoma; Walaa Alahmadi; Janie Larocque; Giorgia Zadra; Yingtian Xie; Shengqing Gu; Qin Tang; Yi Zhang; Sudeepa Syamala; Ji-Heui Seo; Connor Bell; Edward O’Connor; Yang Liu; Edward M. Schaeffer; R. Jeffrey Karnes; Sheila Weinmann; Elai Davicioni; Colm Morrissey; Paloma Cejas; Leigh Ellis; Massimo Loda; Kai W. Wucherpfennig; Mark M. Pomerantz; Daniel E. Spratt; Eva Corey; Matthew L. Freedman; X. Shirley Liu; Myles Brown; Henry W. Long; David P. Labbé
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The role of MYC in transcriptional reprogramming in prostate cancer remains poorly characterized. Here, MYC overexpression antagonizes the canonical AR transcriptional program leading to prostate tumor initiation and progression by disrupting transcriptional pause release at AR-regulated genes.