학술논문
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma
Document Type
article
Author
Amin H. Nassar; Sarah Abou Alaiwi; Sylvan C. Baca; Elio Adib; Rosario I. Corona; Ji-Heui Seo; Marcos A. S. Fonseca; Sandor Spisak; Talal El Zarif; Viktoria Tisza; David A. Braun; Heng Du; Monica He; Abdallah Flaifel; Michel Alchoueiry; Thomas Denize; Sayed G. Matar; Andres Acosta; Sachet Shukla; Yue Hou; John Steinharter; Gabrielle Bouchard; Jacob E. Berchuck; Edward O’Connor; Connor Bell; Pier Vitale Nuzzo; Gwo-Shu Mary Lee; Sabina Signoretti; Michelle S. Hirsch; Mark Pomerantz; Elizabeth Henske; Alexander Gusev; Kate Lawrenson; Toni K. Choueiri; David J. Kwiatkowski; Matthew L. Freedman
Source
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
The epigenomic landscape of renal cell carcinoma (RCC) remains to be explored. Here, integrative epigenomic analysis of primary human RCC samples and RCC GWAS risk SNPs identifies transcription-factor specific subtypes and enrichment of risk variants in allelically-imbalanced peaks.