학술논문
Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 2; referees: 2 approved]
Document Type
article
Author
Victoria E. Jackson; Jeanne C. Latourelle; Louise V. Wain; Albert V. Smith; Megan L. Grove; Traci M. Bartz; Ma'en Obeidat; Michael A. Province; Wei Gao; Beenish Qaiser; David J. Porteous; Patricia A. Cassano; Tarunveer S. Ahluwalia; Niels Grarup; Jin Li; Elisabeth Altmaier; Jonathan Marten; Sarah E. Harris; Ani Manichaikul; Tess D. Pottinger; Ruifang Li-Gao; Allan Lind-Thomsen; Anubha Mahajan; Lies Lahousse; Medea Imboden; Alexander Teumer; Bram Prins; Leo-Pekka Lyytikäinen; Gudny Eiriksdottir; Nora Franceschini; Colleen M. Sitlani; Jennifer A. Brody; Yohan Bossé; Wim Timens; Aldi Kraja; Anu Loukola; Wenbo Tang; Yongmei Liu; Jette Bork-Jensen; Johanne M. Justesen; Allan Linneberg; Leslie A. Lange; Rajesh Rawal; Stefan Karrasch; Jennifer E. Huffman; Blair H. Smith; Gail Davies; Kristin M. Burkart; Josyf C. Mychaleckyj; Tobias N. Bonten; Stefan Enroth; Lars Lind; Guy G. Brusselle; Ashish Kumar; Beate Stubbe; Understanding Society Scientific Group; Mika Kähönen; Annah B. Wyss; Bruce M. Psaty; Susan R. Heckbert; Ke Hao; Taina Rantanen; Stephen B. Kritchevsky; Kurt Lohman; Tea Skaaby; Charlotta Pisinger; Torben Hansen; Holger Schulz; Ozren Polasek; Archie Campbell; John M. Starr; Stephen S. Rich; Dennis O. Mook-Kanamori; Åsa Johansson; Erik Ingelsson; André G. Uitterlinden; Stefan Weiss; Olli T. Raitakari; Vilmundur Gudnason; Kari E. North; Sina A. Gharib; Don D. Sin; Kent D. Taylor; George T. O'Connor; Jaakko Kaprio; Tamara B. Harris; Oluf Pederson; Henrik Vestergaard; James G. Wilson; Konstantin Strauch; Caroline Hayward; Shona Kerr; Ian J. Deary; R. Graham Barr; Renée de Mutsert; Ulf Gyllensten; Andrew P. Morris; M. Arfan Ikram; Nicole Probst-Hensch; Sven Gläser; Eleftheria Zeggini; Terho Lehtimäki; David P. Strachan; Josée Dupuis; Alanna C. Morrison; Ian P. Hall; Martin D. Tobin; Stephanie J. London
Source
Wellcome Open Research, Vol 3 (2018)
Subject
Language
English
ISSN
2398-502X
Abstract
Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and the ratio of FEV1 to FVC (FEV1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P