학술논문
The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
Document Type
article
Author
Raphael Romano Bruno; Bernhard Wernly; Hans Flaatten; Jesper Fjølner; Antonio Artigas; Philipp Heinrich Baldia; Stephan Binneboessel; Bernardo Bollen Pinto; Joerg C. Schefold; Georg Wolff; Malte Kelm; Michael Beil; Sigal Sviri; Peter Vernon van Heerden; Wojciech Szczeklik; Muhammed Elhadi; Michael Joannidis; Sandra Oeyen; Eumorfia Kondili; Brian Marsh; Jakob Wollborn; Finn H. Andersen; Rui Moreno; Susannah Leaver; Ariane Boumendil; Dylan W. De Lange; Bertrand Guidet; Christian Jung; COVIP study group
Source
Annals of Intensive Care, Vol 12, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
2110-5820
Abstract
Abstract Purpose Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group. Methods The COVIP study is a prospective international observational study that recruited ICU patients ≥ 70 years admitted with COVID-19 (NCT04321265). Several parameters including ADL (ADL; 0 = disability, 6 = no disability), Clinical Frailty Scale (CFS), SOFA score, intensive care treatment, ICU- and 3-month survival were recorded. A mixed-effects Weibull proportional hazard regression analyses for 3-month mortality adjusted for multiple confounders. Results This pre-specified analysis included 2359 patients with a documented ADL and CFS. Most patients evidenced independence in their daily living before hospital admission (80% with ADL = 6). Patients with no frailty and no disability showed the lowest, patients with frailty (CFS ≥ 5) and disability (ADL