학술논문
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity
Document Type
article
Author
Wuji Zhang; Brendon Y. Chua; Kevin J. Selva; Lukasz Kedzierski; Thomas M. Ashhurst; Ebene R. Haycroft; Suzanne K. Shoffner-Beck; Luca Hensen; David F. Boyd; Fiona James; Effie Mouhtouris; Jason C. Kwong; Kyra Y. L. Chua; George Drewett; Ana Copaescu; Julie E. Dobson; Louise C. Rowntree; Jennifer R. Habel; Lilith F. Allen; Hui-Fern Koay; Jessica A. Neil; Matthew J. Gartner; Christina Y. Lee; Patiyan Andersson; Sadid F. Khan; Luke Blakeway; Jessica Wisniewski; James H. McMahon; Erica E. Vine; Anthony L. Cunningham; Jennifer Audsley; Irani Thevarajan; Torsten Seemann; Norelle L. Sherry; Fatima Amanat; Florian Krammer; Sarah L. Londrigan; Linda M. Wakim; Nicholas J. C. King; Dale I. Godfrey; Laura K. Mackay; Paul G. Thomas; Suellen Nicholson; Kelly B. Arnold; Amy W. Chung; Natasha E. Holmes; Olivia C. Smibert; Jason A. Trubiano; Claire L. Gordon; Thi H. O. Nguyen; Katherine Kedzierska
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The immune response to SARS-CoV-2 infection is variable but has been linked to prognosis and the development of severe immunopathology. Here the authors assess a range of immune parameters in both peripheral blood and respiratory samples, providing a comparative assessment of the immune response between these compartments and their potential impact on immune-pathogenesis.