학술논문
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Document Type
article
Author
Athea Vichas; Amanda K. Riley; Naomi T. Nkinsi; Shriya Kamlapurkar; Phoebe C. R. Parrish; April Lo; Fujiko Duke; Jennifer Chen; Iris Fung; Jacqueline Watson; Matthew Rees; Austin M. Gabel; James D. Thomas; Robert K. Bradley; John K. Lee; Emily M. Hatch; Marina K. Baine; Natasha Rekhtman; Marc Ladanyi; Federica Piccioni; Alice H. Berger
Source
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sensitivity to Aurora kinase inhibitors.