학술논문
Multi-modal molecular programs regulate melanoma cell state
Document Type
article
Author
Miles C. Andrews; Junna Oba; Chang-Jiun Wu; Haifeng Zhu; Tatiana Karpinets; Caitlin A. Creasy; Marie-Andrée Forget; Xiaoxing Yu; Xingzhi Song; Xizeng Mao; A. Gordon Robertson; Gabriele Romano; Peng Li; Elizabeth M. Burton; Yiling Lu; Robert Szczepaniak Sloane; Khalida M. Wani; Kunal Rai; Alexander J. Lazar; Lauren E. Haydu; Matias A. Bustos; Jianjun Shen; Yueping Chen; Margaret B. Morgan; Jennifer A. Wargo; Lawrence N. Kwong; Cara L. Haymaker; Elizabeth A. Grimm; Patrick Hwu; Dave S. B. Hoon; Jianhua Zhang; Jeffrey E. Gershenwald; Michael A. Davies; P. Andrew Futreal; Chantale Bernatchez; Scott E. Woodman
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The regulation of the distinct intrinsic phenotypic states in melanoma remain poorly characterised. Here, multi-omics analysis for a panel of 68 early passage melanoma cell lines reveals that cancer cell intrinsic transcriptomic programs are associated with distinct immune features.