학술논문
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer
Document Type
article
Author
Aritro Nath; Patrick A. Cosgrove; Hoda Mirsafian; Elizabeth L. Christie; Lance Pflieger; Benjamin Copeland; Sumana Majumdar; Mihaela C. Cristea; Ernest S. Han; Stephen J. Lee; Edward W. Wang; Sian Fereday; Nadia Traficante; Ravi Salgia; Theresa Werner; Adam L. Cohen; Philip Moos; Jeffrey T. Chang; David D. L. Bowtell; Andrea H. Bild
Source
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to treatment and clonal heterogeneity in HGSOC.