학술논문
GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
Document Type
article
Author
Daniel Eriksson; Ellen Christine Røyrvik; Maribel Aranda-Guillén; Amund Holte Berger; Nils Landegren; Haydee Artaza; Åsa Hallgren; Marianne Aardal Grytaas; Sara Ström; Eirik Bratland; Ileana Ruxandra Botusan; Bergithe Eikeland Oftedal; Lars Breivik; Marc Vaudel; Øyvind Helgeland; Alberto Falorni; Anders Palmstrøm Jørgensen; Anna-Lena Hulting; Johan Svartberg; Olov Ekwall; Kristian Johan Fougner; Jeanette Wahlberg; Bjørn Gunnar Nedrebø; Per Dahlqvist; The Norwegian Addison Registry Study Group; The Swedish Addison Registry Study Group; Per Morten Knappskog; Anette Susanne Bøe Wolff; Sophie Bensing; Stefan Johansson; Olle Kämpe; Eystein Sverre Husebye
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).