학술논문
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
Document Type
article
Author
Quinn T. Ostrom; Ben Kinnersley; Margaret R. Wrensch; Jeanette E. Eckel-Passow; Georgina Armstrong; Terri Rice; Yanwen Chen; John K. Wiencke; Lucie S. McCoy; Helen M. Hansen; Christopher I. Amos; Jonine L. Bernstein; Elizabeth B. Claus; Dora Il’yasova; Christoffer Johansen; Daniel H. Lachance; Rose K. Lai; Ryan T. Merrell; Sara H. Olson; Siegal Sadetzki; Joellen M. Schildkraut; Sanjay Shete; Joshua B. Rubin; Justin D. Lathia; Michael E. Berens; Ulrika Andersson; Preetha Rajaraman; Stephen J. Chanock; Martha S. Linet; Zhaoming Wang; Meredith Yeager; GliomaScan consortium; Richard S. Houlston; Robert B. Jenkins; Beatrice Melin; Melissa L. Bondy; Jill. S. Barnholtz-Sloan
Source
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.