학술논문
Palladium-catalyzed 2,5-diheteroarylation of 2,5-dibromothiophene derivatives
Document Type
article
Source
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 2912-2919 (2014)
Subject
Language
English
ISSN
1860-5397
Abstract
Conditions allowing the one pot 2,5-diheteroarylation of 2,5-dibromothiophene derivatives in the presence of palladium catalysts are reported. Using KOAc as the base, DMA as the solvent and only 0.5–2 mol % palladium catalysts, the target 2,5-diheteroarylated thiophenes were obtained in moderate to good yields and with a wide variety of heteroarenes such as thiazoles, thiophenes, furans, pyrroles, pyrazoles or isoxazoles. Moreover, sequential heteroarylation reactions allow the access to 2,5-diheteroarylated thiophenes bearing two different heteroaryl units.