학술논문
Characteristics of resuscitation, and association between use of dynamic tests of fluid responsiveness and outcomes in septic patients: results of a multicenter prospective cohort study in Argentina
Document Type
article
Author
Arnaldo Dubin; Cecilia Loudet; Vanina S. Kanoore Edul; Javier Osatnik; Fernando Ríos; Daniela Vásquez; Mario Pozo; Bernardo Lattanzio; Fernando Pálizas; Francisco Klein; Damián Piezny; Paolo N. Rubatto Birri; Graciela Tuhay; Analía García; Analía Santamaría; Graciela Zakalik; Cecilia González; Elisa Estenssoro; the investigators of the SATISEPSIS group
Source
Annals of Intensive Care, Vol 10, Iss 1, Pp 1-10 (2020)
Subject
Language
English
ISSN
2110-5820
Abstract
Abstract Background Resuscitation of septic patients regarding goals, monitoring aspects and therapy is highly variable. Our aim was to characterize cardiovascular and fluid management of sepsis in Argentina, a low and middle-income country (LMIC). Furthermore, we sought to test whether the utilization of dynamic tests of fluid responsiveness, as a guide for fluid therapy after initial resuscitation in patients with persistent or recurrent hypoperfusion, was associated with decreased mortality. Methods Secondary analysis of a national, multicenter prospective cohort study (n = 787) fulfilling Sepsis-3 definitions. Epidemiological characteristics, hemodynamic management data, type of fluids and vasopressors administered, physiological variables denoting hypoperfusion, use of tests of fluid responsiveness, and outcomes, were registered. Independent predictors of mortality were identified with logistic regression analysis. Results Initially, 584 of 787 patients (74%) had mean arterial pressure (MAP)