학술논문
Identification of 22 susceptibility loci associated with testicular germ cell tumors
Document Type
article
Author
John Pluta; Louise C. Pyle; Kevin T. Nead; Rona Wilf; Mingyao Li; Nandita Mitra; Benita Weathers; Kurt D’Andrea; Kristian Almstrup; Lynn Anson-Cartwright; Javier Benitez; Christopher D. Brown; Stephen Chanock; Chu Chen; Victoria K. Cortessis; Alberto Ferlin; Carlo Foresta; Marija Gamulin; Jourik A. Gietema; Chiara Grasso; Mark H. Greene; Tom Grotmol; Robert J. Hamilton; Trine B. Haugen; Russ Hauser; Michelle A. T. Hildebrandt; Matthew E. Johnson; Robert Karlsson; Lambertus A. Kiemeney; Davor Lessel; Ragnhild A. Lothe; Jennifer T. Loud; Chey Loveday; Paloma Martin-Gimeno; Coby Meijer; Jérémie Nsengimana; David I. Quinn; Thorunn Rafnar; Shweta Ramdas; Lorenzo Richiardi; Rolf I. Skotheim; Kari Stefansson; Clare Turnbull; David J. Vaughn; Fredrik Wiklund; Xifeng Wu; Daphne Yang; Tongzhang Zheng; Andrew D. Wells; Struan F. A. Grant; Ewa Rajpert-De Meyts; Stephen M. Schwartz; D. Timothy Bishop; Katherine A. McGlynn; Peter A. Kanetsky; Katherine L. Nathanson; The Testicular Cancer Consortium
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development and differentiation, and chromosomal segregation.