학술논문
Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy
Document Type
article
Author
Sang T. Kim; Yanshuo Chu; Mercy Misoi; Maria E. Suarez-Almazor; Jean H. Tayar; Huifang Lu; Maryam Buni; Jordan Kramer; Emma Rodriguez; Zulekha Hussain; Sattva S. Neelapu; Jennifer Wang; Amishi Y. Shah; Nizar M. Tannir; Matthew T. Campbell; Don L. Gibbons; Tina Cascone; Charles Lu; George R. Blumenschein; Mehmet Altan; Bora Lim; Vincente Valero; Monica E. Loghin; Janet Tu; Shannon N. Westin; Aung Naing; Guillermo Garcia-Manero; Noha Abdel-Wahab; Hussein A. Tawbi; Patrick Hwu; Isabella C. Glitza Oliva; Michael A. Davies; Sapna P. Patel; Jun Zou; Andrew Futreal; Adi Diab; Linghua Wang; Roza Nurieva
Source
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Arthritis is the most common rheumatic immune-related adverse event (irAE) occurring in cancer patients receiving immune checkpoint inhibitors. Here the authors study the immune landscape of blood and synovial fluid samples from patients with arthritis-irAE, reporting immunological differences and similarities with classic autoimmune arthritis.