학술논문
Tachyarrhythmias During Hospitalization for COVID‐19 or Multisystem Inflammatory Syndrome in Children and Adolescents
Document Type
article
Author
Audrey Dionne; Kevin G. Friedman; Cameron C. Young; Margaret M. Newhams; Suden Kucukak; Ashley M. Jackson; Julie C. Fitzgerald; Laura S. Smallcomb; Sabrina Heidemann; Gwenn E. McLaughlin; Katherine Irby; Tamara T. Bradford; Steven M. Horwitz; Laura L. Loftis; Vijaya L. Soma; Courtney M. Rowan; Michele Kong; Natasha B. Halasa; Keiko M. Tarquinio; Adam J. Schwarz; Janet R. Hume; Shira J. Gertz; Katharine N. Clouser; Christopher L. Carroll; Kari Wellnitz; Melissa L. Cullimore; Sule Doymaz; Emily R. Levy; Katri V. Typpo; Amanda N. Lansell; Andrew D. Butler; Joseph D. Kuebler; Laura D. Zambrano; Angela P. Campbell; Manish M. Patel; Adrienne G. Randolph; Jane W. Newburger
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 20 (2022)
Subject
Language
English
ISSN
2047-9980
Abstract
Background Cardiac complications related to COVID‐19 in children and adolescents include ventricular dysfunction, myocarditis, coronary artery aneurysm, and bradyarrhythmias, but tachyarrhythmias are less understood. The goal of this study was to evaluate the frequency, characteristics, and outcomes of children and adolescents experiencing tachyarrhythmias while hospitalized for acute severe COVID‐19 or multisystem inflammatory syndrome in children. Methods and Results This study involved a case series of 63 patients with tachyarrhythmias reported in a public health surveillance registry of patients aged 1 type was reported in 12 (19%). Registry patients with versus without tachyarrhythmia were older (median age, 15.4 [range, 10.4–17.4] versus 10.0 [range, 5.4–14.8] years) and had higher illness severity on hospital admission. Intervention for treatment of tachyarrhythmia was required in 37 (59%) patients and included antiarrhythmic medication (n=31, 49%), electrical cardioversion (n=11, 17%), cardiopulmonary resuscitation (n=8, 13%), and extracorporeal membrane oxygenation (n=9, 14%). Patients with tachyarrhythmias had longer hospital length of stay than those who did not, and 9 (14%) versus 77 (2%) died. Conclusions Tachyarrhythmias were a rare complication of acute severe COVID‐19 and multisystem inflammatory syndrome in children and adolescents and were associated with worse clinical outcomes, highlighting the importance of close monitoring, aggressive treatment, and postdischarge care.