학술논문
17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil
Document Type
article
Author
Olindo Assis Martins-Filho; Vanessa Peruhype-Magalhāes; Jordana Grazziela Coelho-dos-Reis; Lis Ribeiro Antonelli; Christiane Costa-Pereira; Elaine Speziali; Laise Rodrigues Reis; Jandira Aparecida Lemos; José Geraldo Leite Ribeiro; Luiz Antônio Bastos Camacho; Maria de Lourdes de Sousa Maia; Sheila Maria Barbosa de Lima; Marisol Simões; Reinaldo de Menezes Martins; Akira Homma; Luiz Cosme Cota Malaquias; Pedro Luiz Tauil; Pedro Fernando Costa Vasconcelos; Alessandro Pecego Martins Romano; Carla Magda Domingues; Andréa Teixeira-Carvalho; Ana Carolina Campi-Azevedo
Source
Emerging Infectious Diseases, Vol 25, Iss 8, Pp 1511-1521 (2019)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine–specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF–specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.