학술논문
SARS-CoV-2 antibodies persist up to 12 months after natural infection in healthy employees working in non-medical contact-intensive professions
Document Type
article
Author
Dymphie Mioch; Leonard Vanbrabant; Johan Reimerink; Sandra Kuiper; Esther Lodder; Wouter van den Bijllaardt; Jan Kluytmans; Michel D. Wissing; Hans Augustijn; Marit Bartels; Cornelia H.M. van Jaarsveld; Manon Leemans; Peter van Nierop; Natascha van Riet; Lieke Raaijmakers; Els Reisiger; Chantal Reusken; Ariene Rietveld; Sandra Salewicz
Source
International Journal of Infectious Diseases, Vol 126, Iss , Pp 155-163 (2023)
Subject
Language
English
ISSN
1201-9712
Abstract
Objectives: This study aimed to evaluate dynamics of antibody levels after exposure to SARS-CoV-2 for 12 months in Dutch non-vaccinated hairdressers and hospitality staff. Methods: In this prospective cohort study, blood samples were collected every 3 months for 1 year and analyzed using a qualitative total antibody enzyme-linked immunosorbent assay (ELISA) and a quantitative immunoglobulin (Ig)G antibody ELISA. Participants completed questionnaires, providing information on demographics, health, and work. Differences in antibody levels were evaluated using Mann–Whitney U and Wilcoxon signed-rank tests. Beta coefficients (β) and 95% confidence intervals (CIs) were calculated using linear regression. Results: Ninety-five of 497 participants (19.1%) had ≥1 seropositive measurement before their last visit using the qualitative ELISA. Only 2.1% (2/95) seroreverted during follow-up. Of 95 participants, 82 (86.3%) tested IgG seropositive in the quantitative ELISA too. IgG antibody levels significantly decreased in the first months (P