학술논문
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Thomas, Ashcroft and colleagues use genome-wide CRISPR/Cas9 screening under tumour-relevant metabolic conditions to identify genes that are essential in cancer. Mitochondrial gene essentiality is highlighted, and routes for regulating tumour cell viability in hypoxia are identified.