학술논문
Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death
Document Type
article
Author
Michal Scur; Ahmad Bakur Mahmoud; Sayanti Dey; Farah Abdalbarri; Iona Stylianides; Daniel Medina-Luna; Gayani S. Gamage; Aaron Woblistin; Alexa N. M. Wilson; Haggag S. Zein; Ashley Stueck; Andrew Wight; Oscar A. Aguilar; Francesca Di Cara; Brendon D. Parsons; Mir Munir A. Rahim; James R. Carlyle; Andrew P. Makrigiannis
Source
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Alveolar macrophages (AM) in the lungs maintain surfactant during homeostasis and respond to infectious pathogens. Here the authors show that in the absence of NKR-P1B, pneumococcal infection is more severe because KO AM have increased rates of lipid surfactant uptake and reduced anti-microbial function.