학술논문
Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
Document Type
article
Author
Xiaoguang Xu; James M. Eales; Artur Akbarov; Hui Guo; Lorenz Becker; David Talavera; Fehzan Ashraf; Jabran Nawaz; Sanjeev Pramanik; John Bowes; Xiao Jiang; John Dormer; Matthew Denniff; Andrzej Antczak; Monika Szulinska; Ingrid Wise; Priscilla R. Prestes; Maciej Glyda; Pawel Bogdanski; Ewa Zukowska-Szczechowska; Carlo Berzuini; Adrian S. Woolf; Nilesh J. Samani; Fadi J. Charchar; Maciej Tomaszewski
Source
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
The molecular mechanisms that underlie associations in GWAS, incl. chronic kidney disease (CKD), are largely unknown. Here, the authors perform an integrative analysis of genetic, transcriptomic and epigenomic data from human kidney to pinpoint plausible molecular pathways of CKD genetic associations.