학술논문
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters
Document Type
article
Author
Phanramphoei N. Frantz; Aleksandr Barinov; Claude Ruffié; Chantal Combredet; Valérie Najburg; Guilherme Dias de Melo; Florence Larrous; Lauriane Kergoat; Samaporn Teeravechyan; Anan Jongkaewwattana; Emmanuelle Billon-Denis; Jean-Nicolas Tournier; Matthieu Prot; Laurine Levillayer; Laurine Conquet; Xavier Montagutelli; Magali Tichit; David Hardy; Priyanka Fernandes; Hélène Strick-Marchand; James Di Santo; Etienne Simon-Lorière; Hervé Bourhy; Frédéric Tangy
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Here the authors generate a measles virus-based vaccine expressing SARSCoV-2 spike protein and show immunogenicity and protection in mice and hamsters, including neutralization of circulating variants of concerns in vitro.