학술논문
Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.
Document Type
article
Author
Corina Lesseur; Aida Ferreiro-Iglesias; James D McKay; Yohan Bossé; Mattias Johansson; Valerie Gaborieau; Maria Teresa Landi; David C Christiani; Neil C Caporaso; Stig E Bojesen; Christopher I Amos; Sanjay Shete; Geoffrey Liu; Gadi Rennert; Demetrius Albanes; Melinda C Aldrich; Adonina Tardon; Chu Chen; Liloglou Triantafillos; John K Field; Marion Dawn Teare; Lambertus A Kiemeney; Brenda Diergaarde; Robert L Ferris; Shanbeh Zienolddiny; Stephen Lam; Andrew F Olshan; Mark C Weissler; Martin Lacko; Angela Risch; Heike Bickeböller; Andy R Ness; Steve Thomas; Loic Le Marchand; Matthew B Schabath; Victor Wünsch-Filho; Eloiza H Tajara; Angeline S Andrew; Gary M Clifford; Philip Lazarus; Kjell Grankvist; Mikael Johansson; Susanne Arnold; Olle Melander; Hans Brunnström; Stefania Boccia; Gabriella Cadoni; Wim Timens; Ma'en Obeidat; Xiangjun Xiao; Richard S Houlston; Rayjean J Hung; Paul Brennan
Source
PLoS Genetics, Vol 17, Iss 3, p e1009254 (2021)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta