학술논문
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients
Document Type
article
Author
Raquel Almansa; Silvia Martín; Marta Martin-Fernandez; María Heredia-Rodríguez; Esther Gómez-Sánchez; Marta Aragón; Cristina Andrés; Dolores Calvo; Jesus Rico-Feijoo; Maria Carmen Esteban-Velasco; Luis Mario Vaquero-Roncero; Alicia Ortega; Estefania Gómez-Pesquera; Mario Lorenzo-López; Iñigo López de Cenarruzabeitia; Diana Benavides; Jaime López-Sanchez; Cristina Doncel; Carmen González-Sanchez; Esther Zarca; Alberto Ríos-Llorente; Agustín Diaz; Elisa Sanchez-Barrado; Juan Beltran de Heredia; Jose Maria Calvo-Vecino; Luis Muñoz-Bellvís; Jose Ignacio Gomez-Herreras; César Aldecoa; Eduardo Tamayo; Jesus F. Bermejo-Martin
Source
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Early recognition of sepsis is a key factor to improve survival to this disease in surgical patients, since it allows prompt control of the infectious source. Combining pro-inflammatory and immunosupression biomarkers could represent a good strategy to improve sepsis detection. Here we evaluated the combination of procalcitonin (PCT) with gene expression levels of HLA-DRA to detect sepsis in a cohort of 154 surgical patients (101 with sepsis and 53 with no infection). HLA-DRA expression was quantified using droplet digital PCR, a next-generation PCR technology. Area under the receiver operating curve analysis (AUROC) showed that the PCT/HLA-DRA ratio outperformed PCT to detect sepsis (AUROC [CI95%], p): PCT: 0.80 [0.73–0.88],