학술논문
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.
Document Type
article
Author
Mia M Gaudet; Tomas Kirchhoff; Todd Green; Joseph Vijai; Joshua M Korn; Candace Guiducci; Ayellet V Segrè; Kate McGee; Lesley McGuffog; Christiana Kartsonaki; Jonathan Morrison; Sue Healey; Olga M Sinilnikova; Dominique Stoppa-Lyonnet; Sylvie Mazoyer; Marion Gauthier-Villars; Hagay Sobol; Michel Longy; Marc Frenay; GEMO Study Collaborators; Frans B L Hogervorst; Matti A Rookus; J Margriet Collée; Nicoline Hoogerbrugge; Kees E P van Roozendaal; HEBON Study Collaborators; Marion Piedmonte; Wendy Rubinstein; Stacy Nerenstone; Linda Van Le; Stephanie V Blank; Trinidad Caldés; Miguel de la Hoya; Heli Nevanlinna; Kristiina Aittomäki; Conxi Lazaro; Ignacio Blanco; Adalgeir Arason; Oskar T Johannsson; Rosa B Barkardottir; Peter Devilee; Olofunmilayo I Olopade; Susan L Neuhausen; Xianshu Wang; Zachary S Fredericksen; Paolo Peterlongo; Siranoush Manoukian; Monica Barile; Alessandra Viel; Paolo Radice; Catherine M Phelan; Steven Narod; Gad Rennert; Flavio Lejbkowicz; Anath Flugelman; Irene L Andrulis; Gord Glendon; Hilmi Ozcelik; OCGN; Amanda E Toland; Marco Montagna; Emma D'Andrea; Eitan Friedman; Yael Laitman; Ake Borg; Mary Beattie; Susan J Ramus; Susan M Domchek; Katherine L Nathanson; Tim Rebbeck; Amanda B Spurdle; Xiaoqing Chen; Helene Holland; kConFab; Esther M John; John L Hopper; Saundra S Buys; Mary B Daly; Melissa C Southey; Mary Beth Terry; Nadine Tung; Thomas V Overeem Hansen; Finn C Nielsen; Mark H Greene; Phuong L Mai; Ana Osorio; Mercedes Durán; Raquel Andres; Javier Benítez; Jeffrey N Weitzel; Judy Garber; Ute Hamann; EMBRACE; Susan Peock; Margaret Cook; Clare Oliver; Debra Frost; Radka Platte; D Gareth Evans; Fiona Lalloo; Ros Eeles; Louise Izatt; Lisa Walker; Jacqueline Eason; Julian Barwell; Andrew K Godwin; Rita K Schmutzler; Barbara Wappenschmidt; Stefanie Engert; Norbert Arnold; Dorothea Gadzicki; Michael Dean; Bert Gold; Robert J Klein; Fergus J Couch; Georgia Chenevix-Trench; Douglas F Easton; Mark J Daly; Antonis C Antoniou; David M Altshuler; Kenneth Offit
Source
PLoS Genetics, Vol 6, Iss 10, p e1001183 (2010)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (