학술논문
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology
Document Type
article
Author
Eric A. Hungate; Sapana R. Vora; Eric R. Gamazon; Takaya Moriyama; Timothy Best; Imge Hulur; Younghee Lee; Tiffany-Jane Evans; Eva Ellinghaus; Martin Stanulla; Jéremie Rudant; Laurent Orsi; Jacqueline Clavel; Elizabeth Milne; Rodney J. Scott; Ching-Hon Pui; Nancy J. Cox; Mignon L. Loh; Jun J. Yang; Andrew D. Skol; Kenan Onel
Source
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b.