학술논문
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
Document Type
article
Author
Bill H. Diplas; Xujun He; Jacqueline A. Brosnan-Cashman; Heng Liu; Lee H. Chen; Zhaohui Wang; Casey J. Moure; Patrick J. Killela; Daniel B. Loriaux; Eric S. Lipp; Paula K. Greer; Rui Yang; Anthony J. Rizzo; Fausto J. Rodriguez; Allan H. Friedman; Henry S. Friedman; Sizhen Wang; Yiping He; Roger E. McLendon; Darell D. Bigner; Yuchen Jiao; Matthew S. Waitkus; Alan K. Meeker; Hai Yan
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1.