학술논문
A prospective in silico analysis of interdisciplinary and interobserver spatial variability in post-operative target delineation of high-risk oral cavity cancers: Does physician specialty matter?
Document Type
article
Author
Sweet Ping Ng; Brandon A. Dyer; Jayashree Kalpathy-Cramer; Abdallah Sherif Radwan Mohamed; Musaddiq J. Awan; G. Brandon Gunn; Jack Phan; Mark Zafereo; J. Matthew Debnam; Carol M. Lewis; Rivka R. Colen; Michael E. Kupferman; Nandita Guha-Thakurta; Guadalupe Canahuate; G. Elisabeta Marai; David Vock; Bronwyn Hamilton; John Holland; Carlos E. Cardenas; Stephen Lai; David Rosenthal; Clifton David Fuller
Source
Clinical and Translational Radiation Oncology, Vol 12, Iss , Pp 40-46 (2018)
Subject
Language
English
ISSN
2405-6308
Abstract
Background: The aim of this study was to determine the interdisciplinary agreement in identifying the post-operative tumor bed. Methods: Three radiation oncologists (ROs), four surgeons, and three radiologists segmented post-operative tumor and nodal beds for three patients with oral cavity cancer. Specialty cohort composite contours were created by STAPLE algorithm implementation results for interspecialty comparison. Dice similarity coefficient and Hausdorff distance were utilized to compare spatial differentials between specialties. Results: There were significant differences between disciplines in target delineation. There was unacceptable variation in Dice similarity coefficient for each observer and discipline when compared to the STAPLE contours. Within surgery and radiology disciplines, there was good consistency in volumes. ROs and radiologists have similar Dice similarity coefficient scores compared to surgeons. Conclusion: There were significant interdisciplinary differences in perceptions of tissue-at-risk. Better communication and explicit description of at-risk areas between disciplines is required to ensure high-risk areas are adequately targeted. Keywords: Oral cavity cancer, Target delineation, Post-operative, Interdisciplinary, Interobserver