학술논문
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
Document Type
article
Author
Julie Salomon; Cécile Gaston; Jérémy Magescas; Boris Duvauchelle; Danielle Canioni; Lucie Sengmanivong; Adeline Mayeux; Grégoire Michaux; Florence Campeotto; Julie Lemale; Jérôme Viala; Françoise Poirier; Nicolas Minc; Jacques Schmitz; Nicole Brousse; Benoit Ladoux; Olivier Goulet; Delphine Delacour
Source
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.