학술논문
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.